منابع مشابه
Liver Capsule: FXR agonists against liver disease
E P A T O L O G Y 2011;5303-1312. 3. Ingaki T , M oshetta A , ee Y K , P ng L, Z ao G , D ow es M , et l. R eglation of antcterial deense in he sm ll instine by he nulear ile acid reptor. P oc N tl A ad S ci U S A 2006;7:3920-3925. 4. N eens F , A ndeone P , M azella G , S trsser S I, B ow us C , Invrnizzi P , et l. A placecontrolled tial of obicholic acid in rim ry bliary chongitis. N E gl J M...
متن کاملFatty liver diseases, bile acids, and FXR
The prevalence of nonalcoholic fatty liver disease (NAFLD) worldwide has increased at an alarming rate, which will likely result in enormous medical and economic burden. NAFLD presents as a spectrum of liver diseases ranging from simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and even to hepatocellular carcinoma (HCC). A comprehensive understanding of the mechanism(...
متن کاملTP53 and liver carcinogenesis.
Primary hepatocellular carcinoma (HCC) is one of the most common malignancies and has the fourth highest mortality rate worldwide. The major risk factors, including chronic infections with the hepatitis B or C virus, are exposure to dietary aflatoxin B1(AFB1), vinyl chloride, or alcohol consumption. Southern China and sub-Saharan Africa have the highest dietary AFB1 exposure, making it and hepa...
متن کاملLiver Development, Regeneration, and Carcinogenesis
The identification of putative liver stem cells has brought closer the previously separate fields of liver development, regeneration, and carcinogenesis. Significant overlaps in the regulation of these processes are now being described. For example, studies in embryonic liver development have already provided the basis for directed differentiation of human embryonic stem cells and induced pluri...
متن کاملPromoting Stage of Lung and Skin Carcinogenesis in Mice Carcinogenesis: Spontaneous Liver Carcinogenesis
Although B-carotene has been considered to be a key cancer preventive agent in green and yellow vegetables, other types of carotenoids, such as a-carotene, may also contribute to anticarcinogenic action, since these carotenoids usually coexist with/~-carotene and are detectable in human blood and tissues. In this study, we compared the inhibitory effect of natural a-carotene, obtained from palm...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2014
ISSN: 1671-4083,1745-7254
DOI: 10.1038/aps.2014.117